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KMID : 0358320060470060661
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Korean Journal of Urology
2006 Volume.47 No. 6 p.661 ~ p.666
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Downregulation of Peroxisome Proliferator-Activated Receptor(PPAR)α, PPARγ, and Phosphoglycerate Mutase 2 in Prostate Cancer
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Cho Hyuk-Jin
Kim Duk-Yoon
Kim Jung-Wook
Yoo Tag-Keun
Yang Eun-Kyoung
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Abstract
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Purpose: To evaluate whether factors related to lipid and glucose metabolism have a potential role in the progression of prostate cancer, we measured the mRNA levels of the peroxisome proliferator-activated receptor(PPAR), fatty acid elongase(ELOVL), and two glycolytic enzymes in prostate cancer(CaP) tissues.
Materials and Methods: Prostate tissues, obtained from radical prostatectomy(n=10) and transurethral resection of prostate(n=18), were quickly frozen in liquid nitrogen for RNA measurements. Transcript signals of PPARα, PPARγ, ELOVL2, ELOVL5, phosphoglycerate kinase 1(PgK1) and phosphoglycerate mutase 2(PgM2) were measured using a reverse- transcription polymerase chain reaction.
Results: The transcript signals of PPARα and PPARγ were down-regulated in CaP tissues. In addition, the mRNA level of PgM2 in CaP tissues was lower than that in benign prostatic hyperplasia(BPH) tissues. However, the messages for ELOVL2, ELOVL5, and PgK1 were not significantly changed.
Conclusions: These results suggest that lowering of the PPARα, PPARγ and PgM2 messages may be involved in aberrant and uncontrolled prostate cell growth and differentiation. (Korean J Urol 2006;47:661-666)
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KEYWORD
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Prostate cancer, Peroxisome proliferator-activated receptors, Phosphoglycerate mutase
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